P03-012-B - Lupus erythematous chronicus: a new etiology of macrocheilitis

Methods Mrs. E.F a 30 years old woman, was followed up, since 2003, for a lupus erythematous chronicus. In 2010, she presented a painful cheilitis of the upper lip that gradually increases in volume. Clinical examination showed a scaly macrocheilitis, the rest of the clinical examination was within normal limits. The labial biopsy showed a dyskeratotic hyperkeratosis, keratotic plugs, a pseudo-epitheliomatous hyperplasia, an inflammatory infiltrate of the chorion without granuloma, a direct immunofluorescence that was negative, antinuclear antibodies were positive at 1/80, anti-native DNA antibodies were negative. The systematization work up was unremarkable. The diagnosis of lupus erythematous chronicus was retained. The patient was put under Chloroquine at 4mg/kg/day dose causing total regression of symptoms within 6 months without recurrence for one year.